Lyophilization is an effective method for preserving biological materials such as proteins, enzymes, exosomes, and vaccines by removing water from the sample while maintaining its structure and function. While lyophilization can reduce microbial activity by removing water essential for microbial growth, it typically does not outright “kill” bacteria. The primary mechanism by which lyophilization inhibits […]
Glossary
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Tag: vaccines
Biologic Lyophilization
Biologic lyophilization is a process commonly used in the pharmaceutical and biotech industries to preserve biological substances such as proteins, peptides, antibodies, and vaccines. The process involves freezing the biological material and then subjecting it to reduced pressure, allowing the frozen water to sublimate directly from solid to gas without passing through the liquid phase. […]
Does Lyophilization Degrade RNA?
Lyophilization is commonly used to preserve biological materials such as proteins, enzymes, vaccines, and other biomolecules including RNA. While lyophilization can be beneficial for long-term storage of RNA by removing water and preventing degradation from enzymatic activity, it can also potentially cause damage to RNA molecules if not performed properly. To minimize RNA degradation during […]
BCG Reagents
BCG reagents typically refer to Bacillus Calmette-Guérin (BCG) reagents, which are biological products derived from attenuated strains of Mycobacterium bovis, a bacterium closely related to the one causing tuberculosis (Mycobacterium tuberculosis). BCG reagents play a significant role in tuberculosis control programs, medical research, and clinical practice, contributing to the prevention, diagnosis, and treatment of tuberculosis […]
Advantages of Lyophilization
Lyophilization, commonly known as freeze-drying, is a technique in scientific and industrial realms, offering many of advantages. First, it serves as a guardian of delicate substances, such as proteins, enzymes, and vaccines, safeguarding their biological activity through the gentle removal of water under low-temperature conditions. This preservation of activity is further complemented by its ability […]